“I am thrilled that the LouLou Foundation chose to support research aimed at testing therapeutics in preclinical models of CDKL5 at the NRI. This generous support will enable rigorous testing that we ...

and regulators and payers asks for demonstration of value to support approval and reimbursement. Today, the Loulou Foundation and the International Foundation for CDKL5 Research (IFCR) are proud ...

41 Since 2007, partly through the advocacy of the family support group, families of an individual with a CDKL5 mutation have been invited to complete an InterRett questionnaire. Families also ...

CDKL5 stands for cyclin-dependent kinase-like 5, a protein whose gene is located on the X chromosome. The CDKL5 gene provides instructions for making a protein that is essential in forming the ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window The Cleveland Clinic is one of the centers of excellence for CDKL5 deficiency disorder research. And as such ...

Patients usually use wheelchairs and require support with all activities of daily living. Zhou and colleagues in 2012 generated "Cdkl5 knockout" mice in which Cdkl5 has a function-destroying ...

In summary, phenotypic and target-based screening of patient-derived CDKL5 organoids identified several promising drug targets and therapeutic candidates that reversed the abnormal neuronal ...

Founded in 2017, the CDKL5 Alliance provides coordination and communication to its thirty-five member organizations and support to fledgling CDD patient family groups as they start to organize ...

Patients usually use wheelchairs and require support with all activities of daily living. Zhou and colleagues in 2012 generated “Cdkl5 knockout” mice in which Cdkl5 has a function-destroying ...

Scientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder ... the publication but also the unwavering support we received from the technical ...