The researchers outfitted CD4+ T cells with synthetic Notch (synNotch ... Then, they tested how well suppressor cells carrying different payloads could counteract cytotoxic CAR T cells in vitro. The ...

Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8 + T cells activate host CD4 + T cells to control tumors with antigen loss Xiao et al. report that adoptively transferred tumor ...

They also respond in different ways. Even T cells don’t just do one thing. Some – the cytotoxic T cells – attack infected cells directly, while others – the T helper cells – support immune responses ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders ...

Figure 1: Cytotoxic activity of T-cell lines generated ... depicted in Figures 1 and 2 (data not shown). Role of CD4 + and CD8 + T-cell subsets. Figure 3: Results of representative experiments ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Researchers cultured murine helper T (CD4-expressing ... of regulatory T cells in limiting the growth of cytotoxic T cells. The heat affects ETC1 and increases oxidative stress in the mitochondria ...