Nature9y
Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells
Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...
The New England Journal of Medicine7d
CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53
S3). Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4, and granzyme B but which did not express TRBC1 ...
Nature1mon
Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T-cell cross-priming
They then quickly migrate into draining lymph nodes where they can prime naive CD4 + and CD8 + T cells 1,2,3,4,5,12,13,14. In the absence of these stimuli (that is, under normal conditions ...
News Medical on MSN13d
Cancer-fighting virus T-VEC helps shrink tough-to-treat skin tumors
Talimogene laherparepvec (T-VEC) demonstrates efficacy in cutaneous BCC, enhancing resectability and altering immune cell ...
Medscape2d
High Immune Activation in Patients With Undetectable Viral Loads and Low CD4-Cell Counts
The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...
openaccessgovernment9d
Personalized medicine in oncology: Small molecule inhibitors, biologics and immunotherapies
Priya Hays, Hays Documentation Specialists, discusses innovations and advancements in the development of personalized cancer ...
Healio18d
Mushroom supplement may slow prostate cancer progression
Treatment with white button mushroom tablets reduced immunosuppressive myeloid-derived suppressor cells (MDSCs), and it also increased cytotoxic ... positive CD4-positive T cells,” as well ...