The Notch signaling pathway, present in insects, worms and vertebrates, is involved in embryonic patterning as well as nervous system and cardiovascular development. It's a way for cells to ...

The notch signaling pathway plays a major role in regulating various cellular processes during development, therefore dysregulation of this pathway can lead to disease. This basic signaling ...

Scientists are the first to prove that the Notch signaling pathway targets heart muscle cells and thus reveal its crucial role in heart development and repair. Almost a century after it was ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

A new study finds that NAD+ break down leads to multi organ scarring, providing now a previously undiscovered pathogenic role of the enzyme CD38 in disease ... "We've defined a pathway that ...

One protein called Notch, which has well-known roles in the ... by preventing them from defaulting to a myeloid developmental pathway, which controls non-lymphocyte cell maturation.