THE formation of bilirubin and its elimination from the body as a waste product of heme catabolism require a series of metabolic alterations and transport processes. Partial or complete failure at ...

The breakdown of red blood cells (RBCs) in the body produces bilirubin. The RBCs have a lifespan of around 120 days, and they renew continually. RBCs contain hemoglobin, which helps transport ...

Once inside the hepatocyte, bilirubin binds to the cytoplasmic transport protein ligandin, which belongs to the glutathione-S-transferases (GST) family. Ligandin has a much higher affinity for ...

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including the critical need to maintain intensive phototherapy continuously during infant transport and admission to another facility. Either a serum TSB or a transcutaneous bilirubin (TcB ...

If your bile duct is blocked, it can’t transport bile or pancreatic juice to your intestines for digestion. This causes bile to build up in your liver and increases bilirubin levels in your blood.

Abnormally high levels of bilirubin in the blood (called hyperbilirubinemia) can be due to abnormalities in the formation, transport, metabolism or excretion of bilirubin. For example, high levels ...

Data from two preclinical studies, one involving a mouse model of inflammatory bowel disease 1 and the other a mouse model of pancreatitis, 2 support the therapeutic effects of administrations of ...

Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Cell Chemical Biology , 2019; DOI: 10.1016/j.chembiol.2019.07.006 Cite This Page : ...

High bilirubin levels in newborns may be natural and temporary. However, high bilirubin in adults could be a sign of an underlying health condition, such as jaundice, gallstones, and liver issues.