Now, U-M scientists have determined the structure of a complex of two proteins—BRCA2 together with MEILB2—that allows repairs to happen efficiently in cells undergoing cell-splitting ...

The 3,418-amino-acid BRCA2 protein localizes to the nucleus during ... interaction between BRCA2 and RAD51 prompted us to take a structure-based approach to analysis. Here, we report the 1.7 ...

Scientists have taken pictures of the BRCA2 protein for the first time ... purified the protein and used electron microscopy to reveal its structure and how it interacts with other proteins and DNA.

Together, BRCA2, BCDX2 and RAD51 are the main players ... DeepMind's AlphaFold2 (a computer program which can predict a protein's 3D structure), cryo-EM and high-resolution imaging techniques ...

A University of Iowa-led study has revealed the unexpected structure adopted ... defects in BRCA1 and BRCA2 genes." Cancers with DNA repair deficiencies depend on other proteins to provide backup ...

Next they bombarded the crystals with X-rays and used the resulting diffraction patterns to uncover the three dimensional structure of the protein. Then, they showed that BRCA2 binds to DNA ...

Now scientists have determined the structure of a complex of two proteins -- BRCA2 together with MEILB2 -- that allows repairs to happen efficiently in cells undergoing cell-splitting, called meiosis.

The study found that BRCA2 proteins work in pairs - which the researchers ... T. Shahid et al. 'Structure and Mechanism of Action of the BRCA2 Breast Cancer Tumor Suppressor.' ...