We ask from what type of DNA damage are these proteins protecting ... which suggests that it is the BRCA1–BRCA2–HR pathway that suppresses tumorigenesis.

The Fanconi anemia pathway is part of the DNA-damage network including breast cancer–susceptibility proteins BRCA1 and BRCA2. This pathway is activated by the ataxia telangiectasia and Rad3 ...

The St. Jude researchers demonstrated that the Brca2 gene plays a dual role in ... of the cerebellum greatly increases the risk of DNA damage. So the cell must have a way to ensure that the ...

The pathway -- which has been found to be upregulated in many patients with hereditary breast cancer, ovarian cancer, and prostate cancer, specifically those involving BRCA1 and BRCA2 mutations ...

The St. Jude researchers demonstrated that the Brca2 gene plays a dual role in ... of the cerebellum greatly increases the risk of DNA damage. So the cell must have a way to ensure that the ...

"The DNA inside our cells is constantly experiencing damage, and DNA repair is happening ... The team also found that cancer ...

BRCAness refers to tumors that mimic BRCA1/2 mutation behavior, making them vulnerable to DNA-damaging treatments like PARP ...

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers ... ATM alterations and BRCA1 and BRCA2 defects, including patients previously ...