But now a blitzkrieg of biology has hacked the secret cache of life-and-death data. By deliberately causing every possible mutation of the kind that occurs most commonly in BRCA1, and tracking how ...

And large-scale methods like those described in this Nature paper could start generating a lot more data a lot more quickly. Starita and Shendure aren’t done with BRCA1 yet. The entire coding ...

A total of 238 women with breast cancer before age 50 or ovarian cancer at any age and at least one first- or second-degree relative with either diagnosis underwent sequence analysis of BRCA1 followed ...

The team noted that they generated spatial proteomic data for 21 markers in 124,623 single cells from 112 tumor cores originating from 31 tumors with BRCA1/2 mutation, and from 13 tumors without ...

Clinicians are currently worried that breast cancer patients with low or absent BRCA1 may become resistant to therapeutic agents such as Olaparib. Our data show that cancer cells without BRCA1 ...

These results should be discussed with young women carrying a BRCA1 mutation as they make contraceptive choices prior to prophylactic salpingo-oophorectomy.* *Relevance section written by JCO ...

Given the current lack of effective treatment options for patients showing PARPi resistance, we believe these data are supportive ... sensitive with a mutated BRCA1 gene, while the third ...