For cancer-suppressor genes like BRCA1, researchers have long hypothesized ... Specifically, these cells contained alterations in the structure and organization of chromatin, the material that ...

We will (i) describe the structure of BRCA1 and how it may contribute to its transcription function; (ii) describe the interaction of BRCA1 with the core transcriptional machinery (RNA polII ...

We have developed this method as an alternative to direct probe/target hybridization, which when used to study mutations in exon 11 of BRCA1 7 ... of secondary structure: perfect-match sequence ...

For cancer-suppressor genes like BRCA1, researchers have long hypothesized ... Specifically, these cells contained alterations in the structure and organization of chromatin, the material that ...

Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA ... the effects of BPS on estrogen receptor-alpha and the BRCA1 gene. Most breast cancers are estrogen receptor positive, and ...

BRCA1 and BRCA2 genes encode for proteins that have important roles in DNA repair and act as tumor suppressors. Though there are differences in the sequence and structure of the proteins produced ...

mRNA-BRCA1 level was assessed in frozen tumor specimens by real-time RT-PCR, whereas ER, HER2, CK5/6, CK17 and cyclin E expression in paraffin embedded specimens by immunohistochemistry. Conclusions: ...