In lymphoma, the mutated BCL6 sits on DNA near apoptosis-promoting genes and keeps them switched off, helping the cancer ...

Mutant BCL6 will abnormally situate near genes that trigger apoptosis, tamping down their activity. This can give cancer cells a kind of immortality. The investigators created a molecule that links ...

Medical professionals call this type of cancer-driving protein an oncogene, and in cancer like lymphoma, BCL6 sits on DNA near genes that promote apoptosis and then keeps them turned off.

The two proteins in question are known as BCL6, an oncogene which suppresses apoptosis-promoting genes in the B-cell lymphoma, and CDK9, an enzyme that catalyzes gene activation instead.

Mutated BCL6 will sit on DNA right near specific genes that promote apoptosis, keeping them switched off so the cancer cells can continue to grow and divide unchecked. To counter this, the ...

Company to showcase preclinical studies of ARV-393, an investigational oral PROTAC BCL6 degrader, as a single agent in models ...

Bcl6 regulates the lineage stability and suppressive ... including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene ...

Bcl6 regulates the lineage stability and suppressive function of Treg cells in head and neck squamous cell carcinoma ...

The BCL6 protein facilitates B cell tolerance of rapid proliferation and somatic gene recombination via repressing cell cycle checkpoints, terminal differentiation, apoptosis, and the DNA damage ...

The BCL6 protein facilitates B cell tolerance of rapid proliferation and somatic gene recombination via repressing cell cycle checkpoints, terminal differentiation, apoptosis, and the DNA damage ...