The balance between pro- and anti-apoptotic activities of BCL-2 family members is tipped towards survival in many cancer cells, thus allowing them to survive various stressful environments ...

Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS Patients had histologically documented SCLC or other nonhematologic malignancies, age ≥ 18, Eastern ...

Sexual dysfunction in nonseminoma testicular cancer patients is related to chemotherapy-induced angiopathy. p53 was not correlated to any patient or tumor characteristic, whereas bcl-2 showed higher ...

and Bcl-2 antagonist killer 1 (Bak), which are crucial regulators of the cell death pathway. This ensured that the cancer cells survived the nutrient-deprived environment. “Our results explain what ...

Kite Pharma’s bicistronic CAR T-cell therapy hit the main goal of a phase 1a trial, with zero dose-limiting toxicities (DLTs) ...

Treeline Biosciences Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) targeting moiety via a ...

San Antonio has one of the highest rates of metabolic dysfunction-associated steatotic liver disease (MASLD) in the United States, largely driven by high rates of obesity and diabetes in the region.

Lilly licensed the ex-China rights to the drug—a selective small-molecule inhibitor of a protein called B-cell ... up BCL-2 as an “increasingly important therapeutic target in cancer biology.” ...

Treeline Biosciences Inc. has described proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xL; Bcl-X; BCL2L1) targeting moiety via ...