But since mutagenesis is random, the probability of B cells acquiring worthless or deleterious mutations far outweighs the chance they'll acquire mutations that enhance their affinity for an antigen.

Renier Brentjens, a CAR T-cell pioneer, views armored CAR T-cells as a promising avenue for treating solid tumors and ...

Once B lymphocytes spot the antigen (antibody generators ... T cells or cell-eating phagocytes. Killer T cells (cytotoxic T lymphocytes) attack other cells. They are particularly useful for ...

This is caused by the attack of the ... specifically remove B-cells from the body, shows their significant contribution to the disease activity of MS. "The target antigen of MS has long been ...

Multi-antigen attack by CO-CTEs can be mediated by biologics ... “ALETA-001, our clinical B-cell lymphoma therapeutic, will provide robust clinical support for all of the Aleta technologies.

A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy ... “The only cell surviving that attack is actually the plasma cell, because the plasma cell has no CD19 ...

The Lupus Research Alliance (LRA) is proud to announce the inaugural recipients of the new Targeted Research Program on Engineered Cell Therapies for Lupus (TRP-ECT) to support the development and ...