Apo-E isoforms differentially regulate Aβ aggregation and clearance in the brain, and have distinct functions in regulating brain lipid transport, glucose metabolism, neuronal signalling ...

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human ...

A new study investigates how APOE isoforms differentially affect human microglia function in Alzheimer's disease ...

New research offers clues into how APOE isoforms affect microglia function differently in Alzheimer's disease, leading to ...

This provides evidence for an interaction of apo(a) genetic variability and kidney function on Lp(a) concentrations. We demonstrate in this investigation a pronounced change in the relative ...

The findings indicated that lower plasma levels of apolipoprotein E were associated with a decrease in cognitive function but did not show any correlation with incident dementia. Furthermore ...

For the first time, this study uncovers a role of APOE as an epigenetic mediator, expanding our understanding of an entirely new function of APOE in mediating senescence.

Outcomes of lung cancer patients with leptomeningeal metastases in the targeted therapy era. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a full ...

We believe that the answer may well be No, because plasma apolipoprotein B (apo B) appears to be a better marker of the risk due to the atherogenic lipoproteins, namely, very low-density lipoprotein ...

Plasma apolipoprotein C3 concentrations, insulin sensitivity, and hepatic triglyceride content were measured. We also measured plasma triglyceride concentrations and retinyl fatty acid ester ...

Patients received the hepatocyte-directed antisense oligonucleotide AKCEA-APO(a)-L Rx, referred to here as APO(a)-L Rx (20, 40, or 60 mg every 4 weeks; 20 mg every 2 weeks; or 20 mg every week ...

A new study suggests how APOE2 is protective while APOE4 increases disease risk by regulating the brain's immune cells.