A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human ...

A new study investigates how APOE isoforms differentially affect human microglia function in Alzheimer's disease ...

LDLR-related protein 1 (LRP1) and the LDLRs are the ... One caveat, however, is that upregulating APOE receptor expression and/or function might increase the risk of other diseases, such as ...

Suppressing complement protein C5 curbed the infiltration of inflammatory ... Previous studies indicated that ApoE expression is high in the ChP, and that increased inflammation there causes cognitive ...

Carrying a particular version of the gene for apolipoprotein E (APOE ... investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic ...

In this study, the researchers found that the expression of APOE protein increased in aging human stem cells and that human stem cell senescence was accelerated upon APOE overexpression and ...

The results also strengthen the idea that was floated several years ago (see ARF related news story) that liver X receptor agonists, which boost expression of both ... enhancing activity of ApoE was ...

ApoE, a protein that is secreted from cells via vesicles, is known not only for its roles in neurodegenerative diseases but also ... Lab safety rules dictate that one must tie back long hair.

A new study suggests how APOE2 is protective while APOE4 increases disease risk by regulating the brain's immune cells.