During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

In addition to the formation of senile plaques and neurofibrillary tangles in brain, the pathological hallmarks of Alzheimer disease (AD), there is substantial neuronal and synaptic loss in the ...

Increasing focus is now being placed on the production of Aβ – a process called proteolysis, during which a precursor protein called amyloid precursor protein (APP) is trimmed by an enzyme ...

Two main protein structures are associated with Alzheimer’s disease: amyloid-beta plaques and neurofibrillary tangles (NFTs). Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor ...

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein (APP) in the central nervous system – was ...

Immunohistochemical analyses using specific antibodies were used to confirm the presence of beta-secretase and amyloid precursor proteins in oligodendrocytes in mice. Post-mortem tissue from ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. The research, published today in eLife, is described by editors as a fundamental study ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. For several decades, researchers studying Alzheimer's disease have been working to ...