The European Medicines Agency (EMA) has designated allopurinol as the first orphan drug for the treatment of Marfan syndrome, a rare connective tissue disease which has no cure to date.

The effects of allopurinol treatment on mortality among patients with gout remain uncertain, with a new meta-analysis finding conflicting results. In a systematic review of the literature that ...

Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease who are at risk for ...

Initiating allopurinol during an acute gout attack doesn't adversely affect the resolution of the attack, according to results of a new placebo-controlled, double-blind study. Allopurinol given ...

(HealthDay)—For patients with gout and chronic kidney disease (CKD), no associations with increased mortality were seen for allopurinol initiation, achieving target serum urate (SU) levels ...

Allopurinol (4-hydroxypyrazolo-(3, 4-d) pyrimidine, HPP), a xanthine oxidase inhibitor, offers a new concept in the prevention of the complications of hyperuricemia. By effectively blocking the ...

Vitamin C supplementation, alone or in combination with allopurinol, appears to have a weak effect on lowering uric acid levels in gout patients, according to the results of a new study.

Allopurinol, a frequently used gout medication, does not appear to drive up the risk for dying among gout patients who also struggle with chronic kidney disease, new research shows. The finding is ...

Certain textbooks/references suggest a maximum dose of allopurinol (Xyloprim, Lopurin) in patients with renal insufficiency. Presumably, this is because of renal excretion of the metabolite ...