This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

"This achievement will promote further understanding of the motility mechanism of how the energy of ATP hydrolysis is converted into gliding motility, and how these motors of Mycoplasma mobile are ...

Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for ...

The researchers specifically focused on the conformational changes in SecA during the ATP hydrolysis cycle, which is critical to the translocation mechanism. The hydrolysis of ATP serves as the ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

acts as the motor domain of the molecule and pulls actin filaments along by repetitive conformational changes coupled to ATP hydrolysis. But to understand fully even this fundamental aspect of ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...

"This achievement will promote further understanding of the motility mechanism of how the energy of ATP hydrolysis is converted into gliding motility, and how these motors of Mycoplasma mobile are ...