The record comes in a season in which the White Sox had multiple double-digit losing streaks and fired manager Pedro Grifol.

The Chicago White Sox now have the dubious distinction of having lost the most games in a modern Major League Baseball season ...

The Chicago White Sox lost their post-1900s, major league-record 121st game Friday night, falling 4-1 to the Detroit Tigers ...

Again, on Wednesday, the White Sox avoided setting the record. Andrew Benintendi walked off the game ... who also rank high ...

The Chicago White Sox have set the record nobody want to make - they lost their 121st game of the season, the most ever in a ...

After listening all week to Chicago White Sox general manager Chris Getz, manager Grady Sizemore and players discussing their ...

Chicago fell to 39-121 to eclipse the 1962 New York Mets for the most losses by a major league team since 1900.

The Chicago White Sox's social media team continues to set a standard the players have failed to match on the field. A day after the White Sox suffered ...

While the Detroit Tigers were celebrating their 4-1 win over the Chicago White Sox that clinched the team's first playoff berth since 2014 on Friday ...

The losses are the most by any Major League Baseball team from 1900 on, with the White Sox breaking the mark of 120 set by ...

The White Sox fired manager Pedro Grifol on Aug. 8 soon after the 21-game losing streak. Interim manager Grady Sizemore is ...

The Chicago White Sox suffered loss No. 121 of the season Friday, breaking the modern-day Major League Baseball record.