The biggest game of the NFL season is taking place in Orchard Park on Sunday, as the Kansas City Chiefs head up to Highmark Stadium to take on the Buffalo Bills (4:25 p.m. ET on CBS) in a battle of the top two teams in the AFC.

When the NFL schedule was released last May, CBS Sports president David Berson acknowledged that his company wanted to maximize the big AFC brands, and the Kansas City Chiefs were a major priority. He was delighted that the Chiefs would appear at least eight times on CBS,

Josh Allen vs. Patrick Mahomes, playoff games and exciting regular seasons games have made this a premier game on the NFL schedule.

Chiefs vs. Bills may be the game of the week. Mahomes and Josh Allen have faced off a total of seven times, with Mahomes winning four of those matchups. However, it's Allen who ha

Continue reading for more insights regarding the Bills vs. Chiefs matchup, including stats, leaders and a predicted winner. Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo.

ESPN believes that Buffalo Bills wide receiver Khalil Shakir could be in for a big game when his team hosts the Kansas City Chiefs in Week 11.

The Buffalo Bills will take a five-game winning streak into their Week 11 showdown with the undefeated Kansas City Chiefs. They will leave with it intact.