The biggest game of the NFL season is taking place in Orchard Park on Sunday, as the Kansas City Chiefs head up to Highmark Stadium to take on the Buffalo Bills (4:25 p.m. ET on CBS) in a battle of the top two teams in the AFC.

When the NFL schedule was released last May, CBS Sports president David Berson acknowledged that his company wanted to maximize the big AFC brands, and the Kansas City Chiefs were a major priority. He was delighted that the Chiefs would appear at least eight times on CBS,

Josh Allen vs. Patrick Mahomes, playoff games and exciting regular seasons games have made this a premier game on the NFL schedule.

Welcome to the Friday edition of the Pick Six newsletter! It's a big week here at CBS Sports and that's because we have a monster game on Sunday with the Bills hosting the Chiefs at 4:25 p.m. ET in what could go down as the biggest regular-season game of the year.

ESPN believes that Buffalo Bills wide receiver Khalil Shakir could be in for a big game when his team hosts the Kansas City Chiefs in Week 11.

The Buffalo Bills will take a five-game winning streak into their Week 11 showdown with the undefeated Kansas City Chiefs. They will leave with it intact.

Most NFL fans are under the belief that the Kansas City Chiefs have dominated the Buffalo Bills in recent years. However, the Bills have held their own, winning 3 of the last 6 meetings between the two teams.