Baxter International has temporarily closed its largest manufacturing plant following damage caused by Hurricane Helene — a move that raises questions about supplies of the medical products it makes there.

The disruption is expected to negatively impact the company’s financial results, according to a statement it released Sunday.

Helene is already one of the deadliest mainland storms in the history of the U.S., with more than 100 people killed in the days since it first made landfall.