Roccamandolfi is a comune in the Province of Isernia in the Italian region Molise, located about 25 kilometres southwest of Campobasso and a…Roccamandolfi is a comune in the Province of Isernia in the Italian region Molise, located about 25 kilometres southwest of Campobasso and about 15 kilometres southeast of Isernia. Roccamandolfi borders the following municipalities: Cantalupo nel Sannio, Castelpizzuto, Gallo Matese, Letino, Longano, San Gregorio Matese, San Massimo and Santa Maria del Molise.