Port Macquarie is a town on the Mid North Coast of New South Wales, Australia, 390 km north of Sydney, and 570 km south of Brisbane, o…Port Macquarie is a town on the Mid North Coast of New South Wales, Australia, 390 km north of Sydney, and 570 km south of Brisbane, on the Tasman Sea coast at the mouth of the Hastings River, and the eastern end of the Oxley Highway. It had a population of 47,974 in 2018, and an estimated population of 50,307 in 2023.