Mestre is a borough of the comune of Venice on the mainland opposite the historical island city in the region of Veneto, Italy. Administratively, Mestre forms the Municipalità di Mestre-Carpenedo, one of the six boroughs or districts of the comune. Sometimes it is considered as a frazione. With 88,552 inhabitants, Mestre is the most populated urban centre of the …Mestre is a borough of the comune of Venice on the mainland opposite the historical island city in the region of Veneto, Italy. Administratively, Mestre forms the Municipalità di Mestre-Carpenedo, one of the six boroughs or districts of the comune. Sometimes it is considered as a frazione. With 88,552 inhabitants, Mestre is the most populated urban centre of the comune. The population of the borough of Mestre-Carpenedo is 89,373.