Cheval-Blanc is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France. It is the seat of the …Cheval-Blanc is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France. It is the seat of the Canton of Cheval-Blanc.