To better understand the MDSC-associated transcriptional network and identify new therapy targets, we herein review recent findings about the C/EBP family regarding their participation in the expansion and function of MDSCs.

In this study, we identify C/EBP-δ as a common mediator that regulates the expansion of MDSCs in tumor conditions as well as VEGFR2 expression in vascular endothelial cells, two important populations of cells that constitute the tumor microenvironment.

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that modulates many biological processes including cell differentiation, motility, growth arrest, proliferation, and cell death.

May 1, 2023 · Moreover, myeloid derived suppressor cells (MDSC), a cell type whose levels are elevated in cancer patients and that limits immune cell function and immune surveillance while promoting tumor angiogenesis and growth, express high levels of C/EBPδ.

5 days ago · Aberrant CEBPD expression and activity are associated with multiple organ diseases, including cardiovascular diseases. ... Lin PC. C/EBP-delta positively regulates MDSC expansion and endothelial ...

We reported that the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions, which induce transcription factor NFI-A to support the generation and expansion of MDSCs in the bone marrow and spleens of septic mice.

Oct 18, 2024 · Transcriptional profiling revealed leukocyte diversity typified by a prominent G-MDSC signature and altered immunometabolic profiles, including hypoxia-inducible factor 1a (HIF1a) that was validated in a mouse model of craniotomy infection.

Sep 20, 2013 · The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that modulates many biological processes including cell differentiation, motility, growth arrest, proliferation, and cell death.

We have found that tumor glycolysis regulates the expression of the secondary isoform of CCAAT/enhancer-bind-ing protein beta (CEBPB), liver-enriched activator protein (LAP), via the AMP-activated protein kinase (AMPK)-ULK1, and auto-phagy-signaling pathways; LAP subsequently controls the expression of G-CSF and GM-CSF in tumor cells and conse-q...

Mar 8, 2023 · CEBPδ-siRNA treated anti-metastatic NK cells regenerated the binding proteins that support sitting in fibrinogen-rich soil, such as vitronectin and thrombospondin, increasing fibrinogen attachment....